Thursday, March 28, 2013

Hands-on with MiiPC, the $99 kid-safe Android PC (video)

Handson with MiiPC, the $99 kidsafe Android PC video

It was only two days ago that ZeroDesktop launched MiiPC, a $99 kid-safe Android PC, and the Kickstarter campaign's already surpassed its $50,000 goal. To jog your memory, MiiPC is an attractive 4.7 x 4.7 x 3.1-inch desktop computer running Android 4.2 (Jelly Bean). It's powered by a 1.2GHz dual-core Marvell New Armada SoC with 1GB of RAM, 4GB of flash storage, WiFi b/g/n and Bluetooth 4.0. The system features an SD card slot in front, a power button on top and a full array of ports in the back, including two USB 2.0, HDMI, analog audio I/O, Ethernet and power.

What makes this device so unique is the software, which is optimized for use with a large screen (up to 1080p), keyboard and mouse. It provides a desktop-class web browsing experience with Flash and runs standard Android apps. MiiPC supports multiple user accounts which can be controlled and monitored remotely in real-time using a companion app for iOS and Android. The idea is for parents to create a safe online environment for their kids by managing their access to the web and to apps. We got the chance to play with a prototype MiiPC yesterday -- read our impressions and watch out hands-on video after the break.

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Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/ghmQs4LrMxY/

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Mo. Senate panel weighs credit card surcharge bill

Mar 26 (Reuters) - Leading money winners on the 2013 PGATour on Monday (U.S. unless stated): 1. Tiger Woods $3,787,600 2. Brandt Snedeker $2,859,920 3. Matt Kuchar $2,154,500 4. Steve Stricker $1,820,000 5. Phil Mickelson $1,650,260 6. Hunter Mahan $1,553,965 7. John Merrick $1,343,514 8. Dustin Johnson $1,330,507 9. Russell Henley $1,313,280 10. Kevin Streelman $1,310,343 11. Keegan Bradley $1,274,593 12. Charles Howell III $1,256,373 13. Michael Thompson $1,254,669 14. Brian Gay $1,171,721 15. Justin Rose $1,155,550 16. Jason Day $1,115,565 17. Chris Kirk $1,097,053 18. ...

Source: http://news.yahoo.com/mo-senate-panel-weighs-credit-152618861.html

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Wednesday, March 27, 2013

Normal brain activity linked to DNA damage

msnbc.com

By Charles Choi
LiveScience

Brain activity from experiences as common as exploring new locations surprisingly damages the noggin's DNA, hinting that such disruptions may be a key part of thinking, learning and memory, researchers say.

This damage normally heals rapidly, but abnormal proteins seen in Alzheimer's disease can increase this damage further, perhaps overwhelming the ability of brain cells to heal it. Further research into preventing this damage might help treat brain disorders, scientists added.

Explorer mice
Scientists analyzed young adult mice after they were placed into new, larger cages with different toys and odors that they were allowed to explore for two hours. They measured brain levels of a protein known as gamma-H2A.X, which accumulates when breaks occur in double-stranded molecules of DNA.

"DNA comes in double strands, and has the shape of a twisted ladder," said researcher Lennart Mucke, a neurologist and neuroscientist at the Gladstone Institute of Neurological Disease and the University of California at San Francisco. "Breaks in one strand, in one rail of the ladder, occur quite frequently, but breaking both takes quite a bit of damage and, in the brain, was thought to happen mostly in the context of disease." [10 Odd Facts About the Brain]

Unexpectedly, the researchers found such breaks also happened in the neurons of perfectly healthy mice, with up to six times more breaks in the neurons of explorer mice than in mice that remained in their home cages.

"Breaks of double strands of DNA seem to be a part of normal healthy brain activity," Mucke told LiveScience.

These DNA breaks occurred in various brain regions, especially in the dentate gyrus, an area necessary for spatial memory.

"It is both novel and intriguing, (the) team's finding that the accumulation and repair of DSBs (double-strand breaks) may be part of normal learning," said neuroscientist Fred Gage, of the Salk Institute, who did not take part in this study.

Mystery of DNA breaks
It remains uncertain why brain activity causes DNA breaks. Active neurons do generate DNA-damaging chemicals such as free radicals, but neurons in lab dishes did not have significantly fewer breaks when given antioxidant molecules that counteract free radicals.

Instead, the researchers suggest these breaks could actually help with the genetic activity linked with mental activity.

"We are now very excited to explore why neuron activity causes these breaks in DNA?? whether these breaks somehow facilitate the rapid conversion of genes into proteins involved in memory and learning and in processing all the information you take in when you do something new," Mucke said.

Many of the DNA breaks were fixed within 24 hours via DNA repair mechanisms in the cells. However, mice genetically engineered to produce a protein fragment known as amyloid beta, which accumulates in the brains of Alzheimer's patients, had more DNA breaks than normal in their brains, a problem that worsened during exploration.

Mice that produce human amyloid beta in their brains often have abnormal brain activity, including epileptic seizures, which can also occur in Alzheimer's patients. The researchers found that blocking this abnormal brain activity with the widely used anti-epileptic drug levetiracetam reduced the number of DNA breaks in the neurons of these mice.

"Levetiracetam is already an FDA-approved drug, and a very small clinical trial has already shown that it could provide some benefits in people with early-stage Alzheimer's," Mucke said. "These findings support the idea that the drug might be able to modify the disease by preventing the accumulation of DNA breaks that may promote its progress."

"We're in the process now of designing a larger-scale carefully controlled clinical trial to see if such a strategy is of benefit," Mucke added. "We encourage people to wait until this data becomes available and not jump the gun and start taking this drug when it hasn't been validated thoroughly yet."

The scientists also found that when mice lacked a protein known as tau, excess amyloid beta no longer caused more DNA breaks.

"Tau is intimately involved with Alzheimer's ? it seems to cooperate with amyloid beta," Mucke said. "In the absence of tau, amyloid beta doesn't seem to elicit detrimental effects. We're in the process of developing strategies to manipulate tau in Alzheimer's, and these findings encourage us to intensify and accelerate these efforts."

The scientists detailed their findings online Sunday in the journal Nature Neuroscience.

Follow?LiveScience @livescience, Facebook?and Google+. Original article on?LiveScience.com.

Copyright 2013 LiveScience, a TechMediaNetwork company. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

Source: http://feeds.nbcnews.com/c/35002/f/653377/s/29f7f79d/l/0Lscience0Bnbcnews0N0C0Inews0C20A130C0A30C250C174566860Enormal0Ebrain0Eactivity0Elinked0Eto0Edna0Edamage0Dlite/story01.htm

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Sunday, March 24, 2013

First Person: Iraq Service Difficult, Scary and Painful -- but We Did Good Work

As we near the 10-year anniversary of the start of the war in Iraq, Yahoo News asked U.S. servicemen and women who served to share their perspectives and discuss how it changed them. Here's one story.

FIRST PERSON | March 20 marked the 10th anniversary of the U.S. invasion of Iraq. I was only 16 years old at the time, and I never knew that six years later I would be there myself.

In many ways, the Iraq War stands as a defining element for my generation. We came of age during a period in which the United States was involved in constant conflict. Many of us have family members or friends who have served overseas, and for the military, it was a time of constant deployments, redeployments, and training in between.

I served as an infantryman in the U.S. Army from 2005 to 2009, and I continue my service in the Army Reserves to this day. In late 2007, I deployed to Taji, Iraq, with the 25th infantry division and returned in early 2009. During that time, my platoon was tasked with conducting numerous raids to capture "high-value targets," or individuals that were wanted for specific things -- orchestrating suicide bombings, attacks on coalition troops, and torture, to name a few.

I still remember the face of a young girl I met on a raid one night. We kicked in her door, waking everyone up as they slept on the floor. We ordered everyone to get up, but she was so weak and sick, she couldn't do it on her own. Her face, ringed with thick black hair, was beautiful, but I doubt she lived much longer.

That girl was a victim of events that were far beyond her control, or that of anyone who was there that night. Perhaps if we hadn't invaded, she would have not gotten sick, or would have had access to good health care. Or maybe she's alive and well by now, with a husband and family. I'll never know.

Many felt the war was unjust, that we should never have invaded in the first place, and that we should have left as soon as possible.

By the time I deployed to Iraq, though, the invasion was done, and the place was a mess. I decided not to concern myself with the right or wrong of the invasion; I just knew that we had a job to do, and we did it. My unit had an 84 percent success rate in our mission to capture high-value targets, and we took a lot of bad people off the streets. Iraq was a safer place when we left then when we arrived. In February 2009, I watched as Iraq held its first peaceful election in years, a moment that showed real progress in our involvement in a bloody civil war.

Shortly after that, we redeployed to the United States. I left active duty, moved back home, and used the GI Bill to go to college. It was the right decision, because as it turned out, I met my wife on my first day of classes.

I'm proud of my service in Iraq because I know that we accomplished something good during our deployment. Even better, my platoon brought every man home alive. It was often difficult and scary and even painful. But we did a good thing there. So 10 years after the invasion, and four years after I came home from my own deployment, I can look back at the war and feel good about my role in it.

Source: http://news.yahoo.com/first-person-iraq-difficult-scary-painful-did-good-213600971.html

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Saturday, March 23, 2013

Nigerian Author Chinua Achebe Dead at 82 (Voice Of America)

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Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/293881029?client_source=feed&format=rss

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Special Report: Inside Putin's central bank surprise

By Douglas Busvine

MOSCOW (Reuters) - "It will be a surprise - you'll like it," President Vladimir Putin said with a smile when asked whether he had decided who should be next head of Russia's central bank.

The former KGB spy said nothing more to reporters but the timing of his comment on March 7, the eve of International Women's Day, sent a coded message that was quickly deciphered.

Before the holiday weekend was out his top economic aide, Elvira Nabiullina, had emerged as the sole viable candidate after months of intrigue and disinformation over who Putin would name to the coveted post.

In an era when central bankers have come to be seen as the high priests of global finance, creating money out of nothing, Putin's choice of the soft-spoken former economy minister delivered as big a surprise to Kremlin watchers as did the election of Pope Francis to the world's 1.2 billion Roman Catholics.

Nabiullina's name, derived from the Arabic for "Prophet of Allah", had not appeared on any shortlist. It was precisely her status as a non-candidate that defined the 49-year-old ethnic Tatar as a compromise choice to head the Bank of Russia, say insiders and analysts.

She is both trusted by Putin but acceptable to his opponents. Her selection reflects the growing challenges that Putin, now a year into his third presidential term, faces in sustaining the personalized system of rule he created after first succeeding Boris Yeltsin in 2000.

Although the Kremlin propagates an image of Putin as a master string-puller at the peak of a unified administration, in reality he is more like a circus master trying to control factions that relentlessly vie for influence, according to longtime political observers.

A slowing economy and growing middle-class discontent have deepened a rift between Putin and his coterie of secret-service alumni known as the siloviki, or "men of power", and the so-called "system liberals" to whom he has always delegated the fiscal and monetary management of Russia's $2 trillion economy.

The liberals' standard bearer, Alexei Kudrin, ran budget surpluses, repaid debts and saved windfall oil revenues in a rainy-day fund during an 11-year term as finance minister until he was ousted in 2011.

But a rising group of Kremlin economists is determined to mobilize state resources to crank up flagging economic growth - including by slashing interest rates, a move that would be anathema to the inflation hawks who until now have been in charge of the central bank.

Putin, 60, considered half a dozen other candidates before finally opting for Nabiullina, according to sources familiar with the process. In choosing a trusted confidante, he has extended his influence but stopped short of provoking an open rift with the liberals. But it was a close call.

"She is probably the most balanced person," said Igor Yurgens, head of the Institute of Contemporary Development, a think tank with close ties to Dmitry Medvedev, the former president who is now prime minister. Nabiullina "has the closest distance to the president. She can influence him," said Yurgens.

Supporters describe Nabiullina as a skilled economist, administrator and negotiator. They emphasize her role in drafting the market reforms of Putin's first term that supported Russia's return to rapid growth after the trauma of the rouble devaluation and domestic debt default of 1998.

"She's serious and she's smart," said Martin Gilman, a former International Monetary Fund staffer who heads the Centre for Advanced Studies at Moscow's Higher School of Economics.

Others are less complimentary, saying Nabiullina exerts tight control over her subordinates and focuses on managing upwards rather than outwards - weaknesses in a central bank boss who needs to be a good delegator and an adept communicator.

Where policy makers and economists agree is that Nabiullina is a compromise choice, lacking independence compared with the central bank's current head, Sergei Ignatyev, who retires in June after 11 years in the job.

"Putin and Medvedev perceived Ignatyev as someone who can take responsibility for what he says or does. His recommendations were in a way seen as an instruction manual," said one senior administration official who requested anonymity.

"Will Elvira have this authority? I doubt it," the official added. "She is one of those people who would understand how things need to be done, as a professional, but realizes that if the Kremlin wants something different, this is what must be done. End of story."

Nabiullina declined to comment, but Gilman defended her independence. "Nabiullina takes the responsibility of public policy very seriously," he said. "She is appreciated within the elite as a technocrat who does her homework and solicits views. She knows her stuff."

KUDRIN'S REJECTION

Putin's "you'll like it" remark had a familiar ring - he used exactly the same phrase when he was prime minister in August 2011, the month before he announced he would run again for the presidency.

On September 24, 2011, when Putin announced that he would swap jobs with Medvedev, his partner in Russia's ruling tandem power structure, then Finance Minister Kudrin was 5,000 miles away in Washington D.C. and most certainly did not like what he heard. Offbase at the autumn meetings of the International Monetary Fund and World Bank, Kudrin - said to harbor prime ministerial ambitions of his own - summoned reporters to a briefing and declared that he would not serve in a Medvedev-led government.

His remarks caused a furor. Medvedev demanded Kudrin's head and the finance minister promptly found himself out of a job.

After the ruling party won the December 2011 parliamentary election with a reduced majority, Putin offered the post of central bank chairman to Kudrin, an old ally who back in 1996 had helped Putin get his first job in the Kremlin.

Kudrin, however, showed some sympathy with demonstrators protesting over what he called "major violations" in the conduct of the elections. In private, he turned down Putin's job offer, sources familiar with the matter say.

Throughout the selection process Kudrin played his cards close to his chest and avoided public comment on the issue. Although he did not completely break with Putin, Kudrin's rejection of the president's offer challenged the code of loyalty Putin relies on to control Russia's bureaucracy.

Asked about Kudrin's political future at a televised call-in show not long after the election, Putin's discomfort was palpable. "Alexei Leonidovich Kudrin has not left my team. We are old comrades, he's my friend," he said.

Putin had miscalculated, says economist Sergei Aleksashenko, who in the 1990s served as a deputy finance minister and later as first deputy chairman of the central bank.

"He (Putin) was sure that Kudrin would accept this position," said Aleksashenko. "Kudrin rejected this proposal. It was a big surprise for Putin. Then he started to look around for who he could rely on."

BATTLE OVER POLICY

Putin's attention turned to Sergey Glazyev, a Soviet-educated economic prodigy and former rival. Glazyev ran against Putin for president in 2004 and, before losing heavily, accused the Russian leader of running a "corrupt and irresponsible regime".

But in February 2012, a month before the presidential election, Glazyev had thrown his lot in with Putin, writing in a blog post that the Russian leader's decisions were "always in the interest of the country". Soon after taking office, Putin appointed Glazyev to a Kremlin role advising on economic integration among post-Soviet states.

Glazyev had made his name as an unorthodox economist, arguing the state should play a leading role in development and spurning the liberal consensus that has sought to bring Russia into the global financial and economic mainstream.

His views soon gained influence, inspiring increasingly strident official calls for the central bank to ease policy to bolster growth that, at 3.4 percent last year, was around half the average rate of Putin's first two terms.

Russia's liberal establishment recoiled at the rise of Glazyev, who is on the record accusing the West of conspiring to turn Russia into an economic colony and who once described the Russian central bank as a branch of the U.S. Federal Reserve.

"A person who argues in all seriousness that the United States and Europe are issuing money so that they can grab Russian assets on the cheap can be anyone as long as he is healthy; just not an economist," Anatoly Chubais, the architect of Russia's 1990s mass privatizations, wrote in January.

Glazyev was unmasked as a contender for the central bank job in February - just over month before the deadline for Putin to make his choice - in an apparent bid by the liberal camp to undermine his candidacy.

He declined to comment to Reuters. But pro-Kremlin commentators rallied to his support, with TV pundit Mikhail Leontyev saying Glazyev was the best man for the central bank job, regardless of whether he was a candidate.

The contest for the central bank job was really a proxy battle, one senior former central banker told Reuters at the time, between the fiscal and monetary orthodoxy personified by Kudrin and the Glazyev state-led dash for growth.

"It's about policies, not about personalities," he said.

NO INSIDER

The name of Alexei Ulyukayev, Ignatyev's most senior deputy at the central bank, appeared as the most credible insider on shortlists that did the rounds in January and February. But his opposition to rate cuts counted against him.

Putin also passed over candidates from Russia's powerful state banks that, many economists argue, bear far greater responsibility for the high cost of borrowing in Russia than the central bank itself.

His eventual choice of Nabiullina caught many by surprise. "I myself learned she was nominated from the internet," a senior government source told Reuters. "I am not kidding. Whoever tells you he knew which candidate Putin would pick long ago is lying."

When her nomination became public, Kudrin tweeted to wish her success.

Nabiullina will face a challenge in bringing Russia's unruly banks to heel. The role is complicated by a plan to transform the central bank into a 'mega-regulator', with added responsibility for oversight of financial markets.

Even senior officials admit huge sums escape the oversight of banking regulators. In unusually forthright remarks Ignatyev, the outgoing central bank chief, said last month that nearly $50 billion was illegally siphoned abroad last year.

Much of that money, Ignatyev said, appeared to be controlled by "one well-organized group of people". He did not name them, but Putin's critics have interpreted the remarks to refer to the state officials who, if not involved, at least tolerate fraud and money laundering by Russian banks.

A QUESTION OF LOYALTY

Nabiullina cut an uncertain figure when Putin proposed the central bank post to her at a meeting on March 12 at his Novo-Ogaryovo residence outside Moscow. Kremlin reporters spotted her waiting, with Ignatyev, more than an hour before the two were ushered into Putin's office.

"I would like to thank you for the confidence you have shown in proposing my candidacy. I understand how much this is a responsible, complex and professional task," she told Putin in a meeting staged in front of journalists.

With television cameras rolling, Nabiullina then requested that, if parliament approves her candidacy, the 65-year-old Ignatyev stay on as an adviser after he retires. Putin agreed.

That may suggest Nabiullina, who advocated pro-growth policies as economy minister but did not launch any landmark initiatives, will not stray far from the policy course demanded by Putin. But it does not mean the system liberals, many of whom sympathize with protestors' calls to fight official corruption and boost democratic accountability, are on board for good.

It was Nabiullina's husband, Yaroslav Kuzminov, rector of the Higher School of Economics, who in April 2011 warned of a social confrontation in five to 10 years if Russia's leaders fail to address the concerns of the rising middle class.

It is that very proximity of potential dissent to the centre of Kremlin power that poses a threat to the fragile cohesion of the Russian elite. For now, Putin has succeeded in keeping the key liberal players inside the tent of Kremlin politics - and his nomination of Nabiullina for the central bank job is part of that strategy. But it will be a tough act to sustain as he likely eyes a fourth presidential term in 2018.

"When Putin switched jobs with Medvedev, it divided society," said a critical Moscow-based economist. "By picking Nabiullina he has divided the country's intellectual elite - even further than it is already divided."

(Additional reporting by Darya Korsunskaya, Alexei Anishchuk, Jason Bush, Lidia Kelly, Maya Dyakina and Katya Golubkova; Editing by Timothy Heritage and Richard Woods)

Source: http://news.yahoo.com/special-report-inside-putins-central-bank-surprise-044452796--business.html

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Thursday, March 21, 2013

OH at baby shower - BabyandBump

For my shower from my family, it will be all women, and I don't expect DH to go and I assume he won't be expected.

Mine at the office is co-ed (obviously, it's the whole office!) and they asked me to make sure he comes.

Mine on DH's side of family is more of a party than a shower, it will be co-ed and may be after the baby arrives. DH and his friends will be there. It's more of a baby celebration party than a baby shower...I think it's going to be a barbeque.

Source: http://babyandbump.momtastic.com/pregnancy-third-trimester/1785745-oh-baby-shower.html

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Wednesday, March 20, 2013

Discovery of new drug to combat malaria

Mar. 20, 2013 ? University of South Florida researchers played a key role in an international multidisciplinary project that has yielded a promising new antimalarial drug with the potential to cure the mosquito-borne disease and block its transmission with low doses.

Roman Manetsch, PhD, USF associate professor of chemistry, and Dennis Kyle, PhD, USF professor of global health, were co-leaders of the USF team, which helped to discover and develop a series of potent compounds to combat malaria known as the 4-(1H)-quinolone-3-diarylethers, or quinolones.

The USF researchers were part of larger Medicines for Malaria Venture (MMV) project team including Oregon Health & Science University in Portland, Drexel University in Philadelphia, and Monash University in Australia.

The researchers narrowed the most effective drug candidates in the quinolones series to one lead drug -- ELQ-300 -- now moving toward clinical testing.

The project team's findings are published today in the journal Science Translational Medicine. USF's Alexis LaCrue, PhD, a research associate in Kyle's laboratory, was a co-first author for the paper along with Aaron Nilsen, PhD, of Portland VA Medical Center.

In initial preclinical tests, the lead drug demonstrated impressive preventive and transmission-blocking -- and a low likelihood for developing rapid resistance to major strains of malaria parasites.

In addition, ELQ-300 could likely be produced more cheaply than existing antimalarial drugs -- a major advantage in treating a tropical disease that kills nearly one million people a year and causes recurring bouts of severe and incapacitating illness, most often among poor people in developing countries.

"This is one of the first drugs ever to kill the malaria parasite in all three stages of its life cycle," said Kyle, a member of the USF College of Public Health's Global Infectious Diseases Research team. "So, it may become part of a new-generation therapy that not only treats sick people and prevents them from getting ill, but also blocks the transmission of malaria from mosquitoes to humans ? If the drug can break the parasite life cycle, we may ultimately eradicate the disease."

New life from an old class of compounds

The new drug class identified by the researchers were derived from the first antimalarial quinolone, endochin, discovered more than 60 years ago but never pursued as a treatment because it appeared not to work in humans.

Using new technology to optimize the quinolones, the MMV project team demonstrated that these compounds were indeed highly effective against Plasmodium falciparum, the most lethal strain of malaria, and Plasmodium vivax, the major cause of malaria outside Africa. The quinolones target both the liver and blood stages of the parasite as well as the forms critical for disease transmission.

"This was a very challenging project requiring years of hard work, collaboration across disciplines, and a good portion of luck," said Manetsch, whose laboratory specializes in medicinal chemistry, drug discovery and development of novel chemical probes to characterize drug-protein interactions.

Optimizing drug success against a complex parasite life cycle

In humans, the malaria parasite targets the liver after it enters the bloodstream through the bite of an infected mosquito. Once inside the liver, the infecting parasites for most types of malaria multiply and rupture liver cells, escaping back into the bloodstream -- although sometimes parasites can remain dormant in the liver for extended periods. The parasites, now modified to attack red blood cells, rapidly create more parasites, which spread throughout the bloodstream in waves.

The researchers needed to find and fine-tune a drug with a long half-life both to prevent malaria and to offer long-term protection against reinfection.

"It was a balancing act to optimize an antimalarial drug so that it was soluble and metabolically stable, without compromising its potency," Manetsch said. "We wanted a compound that within an individual would not break down too quickly, remain circulating in the blood for a long enough period to kill the parasites, and be highly active in blocking transmission in rodent models of malaria."

The antimalarial drug developed needed to be potent enough to work without harmful or bothersome side effects.

ELQ-300 targets a protein complex of the mitochondria that is integral for the energy household of a cell, Manetsch said. That's good when you're trying to incapacitate a malaria parasite's powerhouse, but the same hit in a human's mitochondria could be disastrous, he added.

So, Manetsch, with the help of Kyle's expertise in parasitology, structurally modified the quinolone scaffold so that the drug candidate ELQ-300 would selectively hit only the malaria parasite's target while sparing the human mitochondria.

Antimalarial drug resistance: A global health threat

With the rapid emergence of multi-drug resistant strains of malaria, the need to find new drugs capable of delaying or preventing drug resistance has become even more pressing, researchers say.

The quinolones, including ELQ-300, target the same biological pathway as atovaquone, the main component of Malarone, one of the newest combination drugs used to treat malaria. But, in repeated experiments ELQ-300 did not generate drug-resistant strains of the malaria parasite -- making it a significant improvement over atovaquone.

In addition, the new drug's design makes it more effective at lower doses, hopefully meaning fewer and smaller pills for patients at a lower cost, said Kyle, a technical advisor for the MMV team preparing ELQ-300 for clinical trials.

USF's Kyle and Manetsch, funded by National Institutes of Health grants totaling more than $2.5 million, continue to collaborate on research to identify and develop novel antimalarial drugs.

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The above story is reprinted from materials provided by University of South Florida (USF Health).

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. A. Nilsen, A. N. LaCrue, K. L. White, I. P. Forquer, R. M. Cross, J. Marfurt, M. W. Mather, M. J. Delves, D. M. Shackleford, F. E. Saenz, J. M. Morrisey, J. Steuten, T. Mutka, Y. Li, G. Wirjanata, E. Ryan, S. Duffy, J. X. Kelly, B. F. Sebayang, A.-M. Zeeman, R. Noviyanti, R. E. Sinden, C. H. M. Kocken, R. N. Price, V. M. Avery, I. Angulo-Barturen, M. B. Jimenez-Diaz, S. Ferrer, E. Herreros, L. M. Sanz, F.-J. Gamo, I. Bathurst, J. N. Burrows, P. Siegl, R. K. Guy, R. W. Winter, A. B. Vaidya, S. A. Charman, D. E. Kyle, R. Manetsch, M. K. Riscoe. Quinolone-3-Diarylethers: A New Class of Antimalarial Drug. Science Translational Medicine, 2013; 5 (177): 177ra37 DOI: 10.1126/scitranslmed.3005029

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/~3/xBhto_JfcH4/130320142709.htm

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I Want My M-WiFi

Looking for an Internet connection when out and about may soon become a lot easier. There's been an uptick in public WiFi availability. Recent public WiFi launches include Google's free WiFi project in New York City, starting with parts of Chelsea. London's tube network went hot in 2012 with 92 underground stations WiFi-enabled; Virgin Media is connecting a further 28 stations by the end of March, 2013.

Source: http://ectnews.com.feedsportal.com/c/34520/f/632000/s/29bc6c48/l/0L0Stechnewsworld0N0Crsstory0C775680Bhtml/story01.htm

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My Biz University 03/18 by Home Based Business | Blog Talk Radio

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    On his show, Comedian Rodney Perry covers arts and entertainment, everything from comedy and politics to music and acting, with his signature comedic slant.

  • MashUp Radio is a 30-minute podcast that discusses the fusion of technology, life, culture and science. Host Peter Biddle, engineer and executive for Intel?s Atom Software, dishes up a thought-provoking discussion.

  • Joy Keys provides her listeners with insight to improve their lives mentally, physically, monetarily and emotionally. Past guests on the show have included Meshell Nedegeocello, Blair Underwood, in addition to an impressive list of CEOs, humanitarians and authors.

  • Host Barry Moltz gets small businesses unstuck. He has founded and run small businesses with a great deal of success and failure for more than 15 years. This is a business radio show where he shares all the craziness of small business. It?s that craziness that actually makes it exciting, interesting and totally unpredictable.

  • The Bottom Line Sports Show is hosted by former NBA stars Penny Hardaway, Charles Oakley, Mateen Cleaves. Tune in to get the inside scoop on what's happening in sports today.

  • Hits Radio covers basketball, sports culture and entertainment with past guests including Jason Kidd, Robin Lundberg and Chris Herren.

  • Listeners get an earful on The Halli Casser-Jayne Show, Talk Radio for Fine Minds. Whether it?s the current political cocktail or the latest must-read award-winning book, Halli tackles all topics and likes to stir ? and sometimes shakes ? things up.

  • Official Internet radio show of forthcoming epic paranormal investigation book by Eric Olsen and "Haunted Housewife" Theresa Argie.

  • Award-winning World Footprints is a leading voice in socially responsible travel and lifestyle. Hosts Ian & Tonya celebrate culture and heritage and bring a unique voice to the world of travel.

  • Football Reporters Online is a group of veteran football experts in the fields of coaching, scouting, talent evaluation, and writing/broadcasting/media placement. Combined, the group brings well over 100 years of expertise in sports.

  • Host John Martin interviews the nation's leading entrepreneurs and small biz experts to educate small business owners on how to be successful. Past guests have included Emeril Lagasse and Guy Kawasaki.

  • The Movie Geeks share their passion for the art through interviews with the stars of and creative minds behind your favorite flicks and pay tribute to big-screen legends. From James Cameron and Francis Ford Coppola to Ellen Burstyn and Robert Duvall, The Geeks have got'em all.

  • Sylvia Global presents global conversations pertaining to women, wealth, business, faith and philanthropy. Sylvia has interviewed an eclectic mix from CEOs and musicians to fashion designers and philanthropists including Randolph Duke and Ne-Yo.

  • Mr. Media host Bob Andelman goes one-on-one with the hottest, most influential minds from the worlds of film, TV, music, comedy, journalism and literature. That means A-listers like Kirk Douglas, Christian Slater, Kathy Ireland, Rick Fox, Chris Hansen and Jackie Collins.

  • Paula Begoun, best-selling author of Don't Go to the Cosmetics Counter Without Me, separates fact from fiction on achieving a radiant, youthful complexion at any age. She?s regularly joined by health and beauty experts who offer the latest on keeping your skin in tip-top shape.

  • Source: http://www.blogtalkradio.com/homebasedbusinessuniversity/2013/03/18/my-biz-university

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